My investigations are based on developing paradigms of executive function and decision making as indices of corticostriatal function, sensitive to neuropsychological deficits seen in neurodegenerative conditions and following brain damage. Techniques include fMRI and pharmacology of disease modifying as well as cognitive enhancing drugs, such as levodopa and atomoxetine. Current research interests lie in the domain of Parkinson’s disease and dementia, and developing neuropsychological and neuroimaging methods to improve early and accurate diagnosis, with a view to tailoring pharmacotherapy. In addition to my empirical work in neuroscience, I am interested in philosophical issues surrounding the concept of disorder in the cognitive, affective and psychiatric domains; the social implications of neuroscientific advances.