Biography

As a Gates Cambridge Scholar at the University of Cambridge, I completed my doctoral studies at the MRC Laboratory of Molecular Biology with Dr. David Barford. My work involved using cryo-electron microscopy (Cryo-EM), X-ray crystallography, and nuclear magnetic resonance spectroscopy (NMR) to study cell cycle regulation. My most exciting discovery was solving the molecular mechanism by which phosphorylation of a cell cycle checkpoint protein, Bub1, triggers kinetochore recruitment of another cell cycle checkpoint, Mad1. For this research I was awarded the Inaugural Whelan Young Investigator Award from the International Union of Biochemistry and Molecular Biology (IUBMB) and went on to co-found and lead an IUBMB initiative to support trainees.

After my PhD I returned to the USA, where I am now a protein designer at a Seattle-based start-up company called Monod Bio which uses de novo protein design and machine learning methods to create the next generation of therapeutic biosensors.

Previous Education

University of St Andrews

Links

https://www.linkedin.com/in/elyse-fischer-152335151